Ethyl ester of 6-methyl-2-phenylquinolin-4-carboxylic acid.



llillfi ll? erm ne mzrnn r one ime ALBRECHT THIELE, 0F BERLIN, GERMANY, ASSIGNOE T0 CHEIEKIQCHE FABEIK AVE ACTIEN' (V0313. E. SGHERING), 0F BERLIN, GERMANY.

ETHYL ESTER @IE' G-METEYL-E-PHENYLQU1NGLIN--GARBOIZYLIC ACID.

No Drawing.

1' '0 al whom it may concern:

Be it known that Amnenmrr Tritium, doctor of philosophy, chemist, citizen of th (irerman Empire, residing at Berlin, Gel

many, have invented a new and useful Improvement in Ethyl Ester of fi-lllethylfllhenylquinolin-l-Carboxylic ileitl, of which the following is a specification.

This invention relutes'to the manufacture 1'3 ofthe ethyl ester of tlqnethylQ-phenylquin0- lin-l-carboxylic acid. which is useful in the treatment of gout uml articular rheumatism. The ester has the following: (-onslitution:

It rryslnllizes in white nvmlles and melts I by slowly heating and is and Speeificacicn of letters Patent.

Application files Ia'uue 15, 1912. Serial :il'O. 103,819.

. methyl-Q phenylquinolint-carhom lie Patented Nova 26, EH2.

passed for some hours through an ethylalcoholic solution of G-methyl-Q-phenylquinolin- .-earhoxylie arid saturated in the cold with hydrochh'n'ic acid. The solution is precipitated with water, extracted with ether and the residuum of the ethereal solution recrystallized from alcohol.

l claim as my invention:

The herein deseribal ethyl ester of 6- acid, melting at about 76 C. crystallizing in white needles, being soluble in alcohol, ether and-benzene. and forming salts, substantially as described.

in testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

ALBRECHT THKELE. llitnesses:

HENRY HAsrEn, Vl OLDEMAH HAUPT. 

